Dr. Brent has led independent research groups since 1985, starting at Harvard/MGH. With Sydney Brenner, he helped start the Molecular Sciences Institute in Berkeley (1997) and ran it from 2001 to 2009. He moved to the Division of Basic Sciences at the Fred Hutchinson Cancer Center, where he is a Senior Fellow in Science Studies. He is known for work in the 1980s that established the modular nature of transcription regulators, and for much later work including contributions to understanding biology via protein interactions, the quantitative physiology of intracellular signaling, and contributions to systems biology. For over 25 years he has advised US government bodies on defense against biological attack and emerging infectious disease. In June 2024 he closed his biological laboratory to commit fully to AI × bio safety. He lives in Seattle, Washington.